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A vitamin D analog may help break down pancreatic cancer’s protective defenses, potentially making tumors more vulnerable to chemotherapy and immune attack. A small clinical trial found encouraging responses, especially in patients whose tumors had high levels of the vitamin D re
A two-year randomized clinical trial involving 493 adults with overweight or obesity found that diet soft drinks were essentially as effective as water for long-term weight loss and weight maintenance. Participants drinking beverages sweetened with aspartame, acesulfame-K, or suc
Scientists have linked a gut bacterial compound called ImP to greater Alzheimer’s risk, harmful brain protein buildup, and faster cognitive decline. The finding raises the possibility that reducing ImP in the blood could one day help slow or prevent dementia.
Weak sunlight can still damage skin DNA if you spend enough time outdoors, according to a landmark Australian study. Even UV doses too low to cause visible redness triggered cellular damage that could accumulate over time and contribute to skin cancer risk.
More than half of 16,000 apparently healthy adults had signs of atherosclerosis, with arterial plaques already detectable in about 1 in 13 people ages 18 to 29. Researchers say directly imaging the arteries could reveal hidden cardiovascular disease years or even decades before s
Creatine helped middle-aged adults gain muscle and strength even without a structured workout program in a new 12-week study. When combined with exercise and a calorie-reduced diet, it produced even greater strength gains while helping participants add lean tissue and lose fat. R
Scientists found that immune cells contributing to Alzheimer’s-related brain damage may be activated in lymph nodes outside the brain before traveling into the nervous system. Blocking this pathway in mice dramatically reduced neurodegeneration and preserved cognitive abilities,
Direct oral anticoagulants cut the risk of serious clinical events by 69% in atrial fibrillation patients with an intermediate risk of stroke, according to the randomized SINGLE-AF trial. The benefit was driven mainly by fewer ischemic strokes, with no increase in major bleeding.
Pain and fatigue in rheumatoid arthritis can persist even after inflammation improves, with depression, poor sleep, obesity, smoking, and chronic pain potentially helping sustain symptoms. Researchers say identifying these hidden drivers could prevent unnecessary medication chang
A new analysis suggests mammograms may lead to far less breast cancer overdiagnosis than some earlier studies indicated. Researchers reexamined all eight major randomized screening trials and accounted for differences in follow-up time, screening frequency, and screening after tr
A newly identified breakdown in communication between nerves and muscles could help explain why people lose strength as they age. Researchers were able to improve muscle strength in an animal model by targeting a key protein, raising hopes that some age-related weakness could eve
A large study tracking more than 95,000 people suggests that how you sleep may be linked to your risk of developing dozens of diseases. People who spent more time in REM sleep had lower risks of 83 conditions, including dementia, heart failure, and Parkinson’s disease, while more
A two-year randomized clinical trial involving 493 adults with overweight or obesity found that diet soft drinks were essentially as effective as water for long-term weight loss and weight maintenance. Participants drinking beverages sweetened with aspartame, acesulfame-K, or suc
Pain and fatigue in rheumatoid arthritis can persist even after inflammation improves, with depression, poor sleep, obesity, smoking, and chronic pain potentially helping sustain symptoms. Researchers say identifying these hidden drivers could prevent unnecessary medication chang
Scientists found that prolonged fasting triggers major changes throughout the body, but many of the most interesting effects only appeared after about three days without food. The results suggest fasting may influence health in ways that go beyond weight loss and could eventually
A new nanoparticle therapy reduced lung tumors in mice while also targeting cachexia, the severe muscle wasting that can accompany cancer. By delivering follistatin mRNA directly to tumors, the approach could eventually offer a way to fight both the disease and one of its most da
Scientists have discovered a human gene with a remarkable double life: it appears to play an important role in brain cells while still retaining the ability to jump around the genome. Called BC200, the gene evolved millions of years ago from a mobile piece of DNA known as a trans
Cancer immunotherapy can lose its punch when tumor-fighting T cells become exhausted, but researchers may have found a way to keep them going longer. Scientists at Memorial Sloan Kettering Cancer Center identified a signaling molecule called MEK that can push T cells to burn thro
Scientists have discovered that E-cadherin, a protein best known as the “glue” holding cells and tissues together, has a surprising second job: helping epithelial cells swallow nearby dead cells. Using live zebrafish and mouse embryos, researchers found that cells can dramaticall
Researchers found that just 20 minutes of comfortable walking can rapidly stimulate the gut. Within one to two minutes after exercise, bowel sounds became stronger, more frequent, and lasted longer, suggesting increased intestinal movement. The boost was brief, fading within a fe
A UCLA study links faster brain aging to specific gut bacteria and chemical byproducts, with older-looking brains also associated with poorer memory, focus, and mood. The findings suggest that biological signs of brain aging may appear decades before obvious symptoms and could ev
High-dose vitamin B3 is showing intriguing early promise as an addition to standard glioblastoma treatment, with 82% of patients in a small trial remaining progression-free after six months. Researchers believe niacin may help revive immune cells suppressed by the cancer, but lar
A vitamin D analog may help break down pancreatic cancer’s protective defenses, potentially making tumors more vulnerable to chemotherapy and immune attack. A small clinical trial found encouraging responses, especially in patients whose tumors had high levels of the vitamin D re
Scientists have identified an enzyme that may act as a natural defense against the worsening of fatty liver disease, which affects an estimated 100 million Americans. The enzyme, called UBE2N, helps liver cells clear away damaged mitochondria and break down fat, potentially preve
